ABSTRACT
The rapid global spread of the Covid-19 led to the utilization of online tools for various lecturing activities. Online learning is a change mandated on lecturers and students to achieve significant educational goals, irrespective of time and location. This research investigates factors affecting the use of the videoconferencing app, Zoom in supporting the online lectures. This study is quantitative research with the unified theory of acceptance and the use of technology (UTAUT) model to analyze online learning software acceptance. The research subjects consist of students and lecturers from the University of Bina Sarana Informatika (UBSI) Indonesia. The result shows that the performance and effort expectancies, as well as the social factors, affect users' attitude towards the software use and their behavioral intention. Also, the facilitating conditions affect their attitude with no significant effect on intention. © 2023 Author(s).
ABSTRACT
Background: COVID-19 has spread rapidly around the world. It is necessary to study lung tissue of postmortem COVID19 patients to determine the molecular alteration particularly the role of IL-6 and IL-17 in causing fatality. Background: This study aims to determine the differences in the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients compared to non-COVID-19 patients. This study also aimed to analyze the correlation between the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients. Methods: This research is an observational analytic study with crosssectional approach. The samples were 15 paraffin blocks of post-mortem lung tissue biopsy of COVID-19 patients, and 15 paraffin blocks of inflammatory lung tissue biopsy or surgery of non-COVID-19 patients. IL-6 and IL-17 expressions were evaluated by immunohistochemical procedure. Result: There was a significant difference in the expression of IL-6 in the COVID-19 group and the non-COVID-19 group with a p-value = 0.001 (p < 0.05). There was a significant difference in the expression of IL-17 in the COVID-19 group and the non-COVID-19 group with p-value = 0.001 (p < 0.05). There was a significant correlation between the expressions of IL-6 and IL-17 in the COVID-19 group, with the Spearman coefficient value (rs) of 0.548 with p = 0.034 (p < 0.05). Conclusion: There are differences in the expression of IL-6 and IL-17 between COVID-19 and non-COVID-19 lung tissue. There is a significant correlation between the expressions of IL-6 and IL-17 in post-mortem lung tissue of COVID-19 patients.
ABSTRACT
The use of private vehicles during the Covid-19 pandemic has increased because private vehicles, especially cars, are considered as the safest mode of transportation to maintain distance and prevent transmission of the Covid-19 virus. Based on data from two different Indonesian secondary car market place, a comparison of a price sample of Car X in the city of Surabaya with the specifications for the 2015 to 2018 car years with car milage under 1000 kilometers, the used cars have a variety of prices hence a used car price prediction system is needed so that people can find out the average price of used cars sold in the market. In this study the author will use the Random Forest Regressor as a machine learning algorithm to predict the price of a used car with a dataset from the AtapData website. The reason for choosing the Random Forest Regressor is because the algorithm has the power to handle large amounts of data with high dimensions with categorical and numerical data types. The evaluation method used in this study is the Root Mean Absolute Error which produces a value of 0.55612 for validation data and 0.56638 for testing data, while the evaluation proceed with Mean Absolute Error produces a value of 0.45208 for validation data and 0.47576 for testing data. © 2022 IEEE.
ABSTRACT
Due to the Covid-19 plague, children with hearing misfortune have experienced challenges in learning and practicing sign language due to need of educational services and learning assets. The next considerations for creating an educational mobile learning application to help deaf kids learn Malaysian Sign Language (MSL). The investigation was conducted through gatherings based on inquire about and interviews with subject matter experts. Instructors recommend that within the current circumstance, versatile learning application are the foremost reasonable stage for understudies to memorize or as an extra learning strategy in arrange to educate them well. This research was conducted through research-based and interview sessions with subject matter experts and followed the Multimedia Mobile Content Development (MMCD) methodology as it was shown to help accelerate development activities and ensure that the application would work and execute as planned. Once the application is developed, students from Sekolah Kebangsaan Silabukan in Lahad Datu, Sabah, will participate in beta testing. Based on the results of user acceptance tests, the application has received positive reviews from its target users. As such, the project's goals are said to have been achieved. At the conclusion of the study, the advantages, limitations and future work of Pocket Sign Language were also identified. © 2022 IEEE.
ABSTRACT
COVID-19 is an acute respiratory disease caused by the SARS-CoV-2 virus that has caused a pandemic with symptoms of upper respiratory infection, respiratory failure, and even mortality. Several asymptomatic patients, with no shortness of breath, were found to experience impaired oxygenation in examination for objective data (happy hypoxia). Thus, objective data are needed, including data on inflammatory parameters (TLC, NLR, LDH, CRP, D-dimer and PCT) to monitor the severity and prognosis of COVID-19 patients. This study aimed to evaluate the inflammatory parameters in the initial days of treatment for COVID-19 patients between intubated and non-intubated patients during hospitalization. The study was conducted in the COVID was a retrospective cross-sectional comparative analytical observational study that involved patients' first laboratory examination results. The statistical analysis was performed using Mann Whitney test for numerical data and Chi Square test for categorical data. There were significant differences in inflammatory parameters values in both groups (p<0.01). The TLC values of intubated patients were lower than those of non-intubated patients, while the NLR, LDH, CRP, D-dimer and PCT values of intubated COVID-19 patients were higher than those of non-intubated patients.
ABSTRACT
Background. Physical education learning in the era of the COVID-19 pandemic has a remarkable impact on students' creativity. Objectives. This study aims to determine the effect of applying the inquiry and discovery models in online physical education learning to develop high school students' creativity. Methods. The multiple treatment and control with the pre and post-test procedure were used, while the samples were second-grade students in physical education learning of Senior High School in Bandung, consisting of 3 groups with 30 members each selected using random cluster sampling. The sample consists of 2 experimental and one control group. Experimental groups 1 and 2 received the inquiry and discovery learning model, respectively, while the control group received the conventional for 16 meetings each. Data collection was carried out by filling out a creativity questionnaire through a Google form before and after treatment. Results. The inquiry model has no difference in the average value of creativity compared to the discovery model's class (p=0.066). In contrast, the inquiry and discovery models have a different average creativity value than the class using the conventional/control model (p=0.001). Conclusions. There is no difference in increasing creativity between the inquiry and discovery models. Although the results of the Bonferroni test showed no difference in the mean value of invention in the inquiry model and the discovery model, when compared to the control group, the inquiry model was more effective.
ABSTRACT
Corona virus is a pandemic that has hit globally (COVID-19) and has affected every country. All countries in the world are taking precautionary measures to suppress the spread of this case. Each work unit or business in each country must comply with the policies of the respective state authorities. For this reason, each business unit must implement a fairly strict health protocol for both employees and customers who will enter the office or business area. This is to ensure health protocols by screening employees or customers who will enter the business area. The indicator of measuring the health condition of employees is by knowing whether the employee's body temperature is in accordance with the permitted threshold. Every employee who will enter will be selected with this tool, and if the body temperature exceeds the threshold, then they are not allowed to enter the business area. An internet of things based electronic equipment is designed to help business units implement health protocols. Using ESP32 as a microcontroller and infrared temperature measurement as a marker to be able to decide whether someone is sick or not © 2021 IEEE.
ABSTRACT
Background: Malaria is a constantly challenging problem, notably in the Coronavirus Disease-19 (COVID-19) pandemic. The syndemic condition, malaria-COVID-19 co-infections, had been reported. Our previous study successfully revealed several compounds from Streptomyces hygroscopicus subsp. Hygroscopicus, including nigericin that has both antimalarial and antiviral effects. In malaria infection, Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT) is the potential target for eliminating Plasmodium. Meanwhile, for SARS-CoV-2 infection, MPro is an essential protein for SARS-CoV-2 survival. This research aims to examine the potential effect of nigericin towards Plasmodium and SARS-CoV-2 by assessing its molecular interaction with PfCRT and MPro through molecular docking study. Methods: The protein target PfCRT and MPro were obtained from Protein Data Bank. Nigericin and the control ligand (chloroquine and N3) were obtained from PubChem. The pharmacokinetic analysis was done using SwissADME. Specific molecular docking was conducted using PyRx 0.9 and was visualized using LigPlot and PyMOL. Results: Nigericin has a large molecular weight, leading to the non-fulfillment of the Lipinski rule for oral administration. Through molecular docking study, the binding affinity of the Nigericin-PfCRT complex was -8.1 kcal/mol, and Nigericin-MPro was -8.6 kcal/mol. These binding affinities were stronger than the control ligand. The interaction between Nigericin-PfCRT and Nigericin-MPro share a similar pocket-site and amino acid residues as the control ligands. Conclusion: Nigericin has potential antimalarial and anti-coronavirus effects through molecular docking perspective by assessing the binding affinity and similarity of amino acid residues compared to control. Administration of systemic route can be an option in giving nigericin.
ABSTRACT
Background: Department of Cardiology and Vascular Medicine created a virtual education series about dietary guideline that refers to DASH by adapting the local wisdom of the Surabaya community. Aims: We aimed to evaluate the impact of Airlangga Comprehensive Anti- Hypertensive Diets Virtual Education Series towards knowledge, attitude, practice, and reduction of blood pressure in the primary care setting during COVID-19 pandemic. Methods: This type of online action research is quantitative with a quasi-experimental design that designs using one group pretest-posttest, when this study was conducted in October-December 2020. The population in this study were all patients with hypertension who were treated in Mojo primary health care setting. A purposive sampling technique were done to receive 110 participants using online questionnaire. Results: A total of 110 participants were included in the analysis, 55 in the intervention group and 55 in the control group. Following the Airlangga Comprehensive Anti- Hypertensive Diets Virtual Education Series implementation, the only parameter that showed significant improvement were knowledge and attitude (p<0 .001). There is no significant change in the skill parameters (p=0.131) and blood pressure parameters (p=0.433) . Conclusion: Airlangga Comprehensive Anti-Hypertensive Diets Virtual Education Series implementation in our study population seems to be effective to improve knowledge and attitude of participants, however, this program seems to be ineffective to improve skill and blood pressure reduction in participants. Future study with longer durations and more comprehensive programme needs to be done to scrutinize the clinical impact of this program nationwide.
ABSTRACT
Background. One of the efforts to reduce hypertension rates in the community is through dietary changes that refer to the Dietary Approach to Stop Hypertension guidelines or abbreviated as DASH. However, in the COVID-19 pandemic, there is a significant obstacle regarding the most effective way to transfer knowledge, skill, and attitude towards society. Aims. Department of Cardiology and Vascular Medicine created a virtual education series about dietary guideline that refers to DASH by adapting the local wisdom of the Surabaya community. We aimed to evaluate the impact of Airlangga Comprehensive Anti-Hypertensive Diets Virtual Education Series towards knowledge, attitude, practice, and reduction of blood pressure in the primary care setting during COVID- 19 pandemic. Methods. This type of online action research is quantitative with a quasi-experimental design that designs using one group pretest-posttest, when this study was conducted in October-December 2020. The population in this study were all patients with hypertension who were treated in Mojo primary health care setting. A purposive sampling technique were done to receive 110 participants using online questionnaire. Results. A total of 110 participants were included in the analysis, 55 in the intervention group and 55 in the control group. Following the Airlangga Comprehensive Anti-Hypertensive Diets Virtual Education Series implementation, the only parameter that showed significant improvement were knowledge and attitude (p < 0 .001). There is no significant change in the skill parameters (p = 0.131) and blood pressure parameters (p = 0.433) . Conclusion. Airlangga Comprehensive Anti-Hypertensive Diets Virtual Education Series implementation in our study population seems to be effective to improve knowledge and attitude of participants, however, this program seems to be ineffective to improve skill and blood pressure reduction in participants. Future study with longer durations and more comprehensive programme needs to be done to scrutinize the clinical impact of this program nationwide.
ABSTRACT
The number of COVID-19 patients that continues to increase, has made several countries continue to seek treatment so that they can help COVID-19 patients recover. The increasing number of patients is indicated, because many residents still do not comply with health protocols. WHO explains that one of the important protocols is to use masks correctly. Some residents are reluctant to use masks because it makes communication less clear and breathless. Due to these omissions, this study aims to identify the use of masks. This study is able to identify the proper use of masks, the use of inappropriate masks and the face without a mask. The process of this research begins with creating a training model from several images. The model that has been made is used as a reference for identification using CNN. The results of the accuracy of this study reached "99.35%". © 2021 IEEE.
ABSTRACT
Since its first discovery in late 2019, coronavirus disease 2019 (COVID-19) has been a global burden associated with significant morbidity and mortality. COVID-19 has been correlated with the development of hypercoagulable state that predisposes the patients to a higher risk of thromboembolism. Current evidence suggests higher incidence of thrombosis, particularly venous thrombosis, among hospitalized COVID-19 patients, mostly with critical illness. On the other hand, there is currently no data regarding the incidence of vivid thrombosis in ambulatory patients with mild COVID-19 and the incidence of concomitant arterial and venous thrombosis in COVID-19 is extremely rare. Herein, we describe catastrophic outcomes of concomitant lower limb arterial and venous thrombosis in a patient with mild COVID-19. This report highlights the occurrence of concomitant arterial and venous thrombosis in ambulatory setting and that this phenomenon resulted in catastrophic clinical consequences.
ABSTRACT
BACKGROUND: The spread of Coronavirus Disease 2019 (COVID-19) disease which has not been balanced with effective protocols can create mental health problems which could affect the quality of life;as of today, there is not any research that examines the influence of both factors. AIM: This study purpose was to analyze the mental health status on the quality of life amongst medicine students during COVID-19 period. METHODS: This is a cross-sectional survey on 361 students from Faculty of Medicine Tanjungpura University. This study was conducted from June 2019 to November 2020 by spreading Depression Anxiety Stress Scale questionnaire and a WHOQOL-BREF questionnaire through online. The data analysis was administered using Kruskal–Wallis statistics. RESULT: The students’ mental health status was dominantly on the normal category with depression domain by 323 students (89.5%), anxiety domain by 311 students (86.1%), and stress domain by 343 students (95%). The quality of life measurement was in category medium in all domains which are physical health (88.6%), psychological health (92.5%), social relationships (50.7%), and environment (78.7%). There was significant effect of mental health status of depression and anxiety toward the aspect of physical health, psychological health, and social relationships (p < 0.05). Stress significantly influenced all domains of quality of life, and there was no significant effect of mental health status domain depression (p = 0.051) and anxiety (p = 0.881) toward the environment aspect. CONCLUSION: Students’ mental health status in this research belongs to the category normal with moderate level in quality of life. To compare, there was a significant effect of mental health status toward the quality of life domains. The good application of self-coping mechanisms and the social encouragement from the environment is suitable intervention strategies during the pandemic COVID-19 period. © 2021 Agustina Arundina Triharja Tejoyuwono, Rangga Putra Nugraha, Faisal Kholid Fahdi.
ABSTRACT
BACKGROUND: The emergence of a new strain of coronavirus infection, the coronavirus infection disease 2019 (COVID-19), has been a pandemic burden across the globe. Severe COVID-19, particularly in patients with acute respiratory distress syndrome (ARDS), is associated with increased risk of admission to intensive care unit (ICU), mechanical ventilation, and mortality. Bronchoscopy has been widely employed as an adjunctive therapy in mechanically ventilated patients. However, the use of bronchoscopy in patients with COVID-19 has been strictly limited due to aerosol transmission. CASE REPORT: We reported 3 COVID-19 Cases presented to the hospital with ARDS. All of the patients were immediately intubated to improve oxygenation. During admission, the patients produced immense airway secretions that might have resulted in partial airway obstruction. A conventional tracheal suctioning did not help to promote clinical improvement. We decided to perform bronchoscopy with controlled suctioning by following a very tight protocol to prevent aerosol formation. A significant clinical and respiratory improvement was observed in all patients following bronchoscopy. Three of them were transferred to regular ward, however, one patient died during hospitalization. CONCLUSION: Bronchoscopic procedures may provide significant therapeutic benefits in severe COVID-19 patients. However, it should be kept in mind that this procedure should only be performed with a rigorous protocol to reduce the risk of aerosol generation and subsequent viral transmission.